What fret on the 4th string gives you an E?

To determine what fret on the 4th string gives you an E, it's essential to understand how the guitar's tuning works. The 4th string, also known as the D string, is tuned to D in standard tuning.

When you fret the D string at the 1st fret, you raise the pitch by a half step, producing an E♭. Moving to the 2nd fret raises the pitch another half step, resulting in an E note. This means that playing the 4th string at the 2nd fret produces an E.

The other choices do not produce the desired note. The 1st fret gives an E♭, the 3rd fret gives an F, and the 4th fret results in an F♯. Hence, the clear choice for obtaining an E note on the 4th string is to fret it at the 2nd fret.